Cyclosporin a decreases apolipoprotein e secretion from human macrophages via a protein phosphatase 2b-dependent and atp-binding cassette transporter a1 (abca1)-independent pathway*

HIGHLIGHTS

• who: Maaike Kockx from the (UNIVERSITY) have published the Article: Cyclosporin A Decreases Apolipoprotein E Secretion from Human Macrophages via a Protein Phosphatase 2B-dependent and ATP-binding Cassette Transporter A1 (ABCA1)-independent Pathway*, in the Journal: (JOURNAL) of June/11,/2009
• what: The authors demonstrate for the first time that CsA and other PP2B inhibitors markedly inhibit apoE secretion from human macrophages and that this effect does not occur via suppression of ABCA1 activity.

SUMMARY

As a constituent of plasma lipoproteins, apoE directs movement of lipids from the periphery to . . .

 



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