HIGHLIGHTS
SUMMARY
Depression is considered among the most disabling medical conditions with over 264 million people affected worldwide. There is evidence from the rodent model and in humans that poor metabolizers (PM) present with milder depressive symptoms and larger hippocampus volume compared with other metabolizers (OM). Previous research suggested that the CYP2C19 polymorphism is related to personality in female individuals, to depression traits in young males, and associated with basal ganglia and hippocampal volume in female individuals. This interpretation was challenged by a recent study that did not find any association between CYP2C19 genetic variation, severity . . .
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