Cyslt2r antagonist hami 3379 ameliorates post-stroke depression through nlrp3 inflammasome/pyroptosis pathway in gerbils

HIGHLIGHTS

  • who: Li Zhou et al. from the School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China have published the article: CysLT2R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils, in the Journal: (JOURNAL)
  • what: This study was designed to investigate the role of HM3379 in PSD-induced chronic neuroinflammation and related mechanisms in gerbils. Accumulating evidence, including from the studies , have demonstrated that HM3379 contributes to the improvement of neurological damage in middle cerebral artery occlusion (MCAO), as seen in MCAO-induced rodent models, and to the attenuation . . .

     

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