HIGHLIGHTS
- who: Thomas Chabot from the Published in partnership with The Hormel Institute, University of Minnesota have published the Article: Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency, in the Journal: (JOURNAL)
- what: The authors show in this co-clinical model that the use of gemcitabine (a cytidine analog) leads to a dramatic response of MBD4-deficient UM on tumor progression. The aim of this work was precisely to identify therapies that are active in MBD4-inactivated tumors, independently from the cell context. The authors believe this level of response . . .
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