Cytokimera gil-11 rescued il-6r deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:lifr:il-11r complexes

HIGHLIGHTS

• who: Puyan Rafii from the Institute, Heinrich-Heine-University, Du00fcsseldorf, Germany, Biological and Medical have published the paper: Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes, in the Journal: (JOURNAL) of December/16,/2021
• what: Taken together the experiments showed that albeit the original binding site context of LIF-site III to LIFR is u03b1-receptor independent re-formatting of LIF-site III into the IL-11 scaffold makes the LIF-site III binding u03b1-receptor dependent. All samples in . . .
  

   

  

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