Cytokine secretion via cholesterol-rich lipid raft-associated snares at the phagocytic cup*

HIGHLIGHTS

• who: Jason G. Kay from the Jason GKay, Rachael Z. Murray, Julia K. Pagan, and Jennifer L. Stow, From the Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia Lipopolysaccharide-activated macrophages rapidly synthesize and secrete tumor necrosis factor ␣ (TNF␣) to prime the immune system. Surface delivery of membrane carrying newly synthesized TNF␣ is controlled and limited by the level of soluble, ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins syntaxin , and SNAP-23. Many functions in immune cells are coordinated from lipid rafts in the plasma membrane, and we investigated a possible role for lipid . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.