Cytolytic activity of car t cells and maintenance of their cd4+ subset is critical for optimal antitumor activity in preclinical solid tumor models

HIGHLIGHTS

• who: Marianna Csaplár and collaborators from the Department of Biophysics and Cell Biology, Faculty of Medicine, University of have published the research work: Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antitumor Activity in Preclinical Solid Tumor Models, in the Journal: Cancers 2021, 4301 of /2021/
• what: In parallel, the authors aimed to reveal whether the differentiation state has any impact on the exhaustion state of the CAR T_cell products.
• how: Next the authors cocultured the various HER2-CAR T_cell populations with HER2+ target . . .
  

   

  

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