Cytosolic nadph homeostasis in glucose-starved procyclic trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux*

HIGHLIGHTS

• who: Stefan Allmann from the (UNIVERSITY) have published the article: Cytosolic NADPH Homeostasis in Glucose-starved Procyclic Trypanosoma brucei Relies on Malic Enzyme and the Pentose Phosphate Pathway Fed by Gluconeogenic Flux*, in the Journal: (JOURNAL) of June/21,/2013
• what: The authors show that the oxidative branch of the PPP and the cytosolic MEc isoform can both contribute to and individually sustain the essential NADPH supply in the cytosol of procyclic trypanosomes. The authors provide direct genetic and metabolomic evidence that this is due to gluconeogenic flux by producing glucose 6-phosphate from proline . . .
  

   

  

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