HIGHLIGHTS
- who: Zhi-Chun Ding and collaborators from the Immunotherapy Program, Center, Georgia Health Sciences University, Augusta, GA, USA have published the paper: Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor Effects, in the Journal: (JOURNAL) of 12/07/2011
- what: In light of the unique and pivotal roles of tumor-reactive CD4+ effector T_cells, the authors propose a scenario in which CD4+ effector T_cells act as the "gatekeepers" of the overall host antitumor immunity after chemotherapy, whose functional status (polyfunctional versus tolerized) critically determines the outcome between eradication versus recurrence . . .
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