HIGHLIGHTS
SUMMARY
To the NMDA receptor (NMDAR) co-agonist, D-serine, known to be involved in SCZ pathophysiology and treatment, another atypical D-amino_acid, D-aspartate (DAsp), has been shown to functionally modulate glutamatergic neurotransmission. The authors analyzed the serum concentrations of the other D-amino_acid present in significant amount in humans, such as D-serine, its precursor, L-serine, as well as glycine. HPLC analysis revealed that the patient`s levels of these three amino_acids, as well as D-serine/ Translational Psychiatry 12:305 total serine ratio, were in the range of control values (D . . .
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