Dampening the signals transduced through hedgehog via microrna mir-7 facilitates notch-induced tumourigenesis

HIGHLIGHTS

• who: Tumourigenesis and colleagues from the Instituto de Neurociencias, CSIC-UMH, Alicante, Spain have published the research: Dampening the Signals Transduced through Hedgehog via MicroRNA miR-7 Facilitates Notch-Induced Tumourigenesis, in the Journal: (JOURNAL) of March/25,/2013
• what: The authors show that blocking Hh signal transduction in clones of cells mutant for smoothened also enhance the organizing activity and growth by Delta-Notch signalling in the wing primordium. The authors provide evidence that the microRNA mir-7 and Notch pathway cooperatively dampen Hh signal_transduction via down-regulation of its receptors ihog and boi . . .
  

   

  

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