Ddr2 expression in cancer-associated fibroblasts promotes ovarian cancer tumor invasion and metastasis through periostin-itgb1

HIGHLIGHTS

  • who: Favour A. Akinjiyan and colleagues from the Department of Obstetrics and Gynecology, School of Medicine, Washington University, Center for Reproductive Health Sciences, Washington University, StLouis, MO, USA have published the article: DDR2 Expression in Cancer-Associated Fibroblasts Promotes Ovarian Cancer Tumor Invasion and Metastasis through Periostin-ITGB1, in the Journal: Cancers 2022, 3482 of /2022/
  • what: The authors demonstrate that DDR2 regulates POSTN expression. Using patientderived omentum cancer-associated fibroblasts from high-grade serous ovarian cancers (Om-CAFs), the authors show that DDR2-depletion leads to decreased expression of POSTN. All the patients who . . .

     

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