De ciency in the cell-adhesion molecule impairs hypothalamic crh neuron development and perturbs normal neuroendocrine stress axis function

HIGHLIGHTS

  • who: HPA (hypothalamic-pituitary-adrenal) axis and collaborators from the United States Toho University, Japan have published the research: De ciency in the cell-adhesion molecule impairs hypothalamic CRH neuron development and perturbs normal neuroendocrine stress axis function, in the Journal: (JOURNAL)
  • what: The authors report that dscaml1 deficiency in zebrafish perturbs hypothalamic CRH neuron development and impairs the normal function of the HPI axis. The authors investigated the roles of a conserved neuronal signaling molecule-Down syndrome cell adhesion molecule-like 1 (zebrafish gene: dscaml1; mouse gene: Dscaml1; Human gene: DSCAML1; Protein: DSCAML1). The . . .

     

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