HIGHLIGHTS
- who: Yameng Xu from the Key LaboratoryJiangnan University have published the Article: De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Based on the GSMM yeast 8.4.036, the authors first expanded the model by adding the reactions in Module A-Module C. Then, it was used for in silico simulations by constraint-based flux balance analysis (FBA)37,38 and knockout targets were identified by OptKnock39. Using this approach, the predominant exporter of rubusoside PDR11 was identified and overexpressed, increasing the synthesis of rubusoside . . .
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