HIGHLIGHTS
- who: Andy Hsien-Wei Yeh from the (UNIVERSITY) have published the paper: De novo design of luciferases using deep learning, in the Journal: (JOURNAL) of 19/01/2022
- what: To stabilize the anionic state, the authors focused on the placement of the positively charged guanidinium group of an arginine residue to stabilize the developing negative charge on the imidazopyrazinone group.
SUMMARY
The authors describe a deep-learning-based ‘family-wide hallucination` approach that generates large numbers of idealized protein structures containing diverse pocket shapes and designed sequences that encode them. The . . .
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