De novo mapt mutation g335a causes severe brain atrophy, 3r and 4r phf-tau pathology and early onset frontotemporal dementia

HIGHLIGHTS

• who: Kunie Ando from the (UNIVERSITY) have published the research work: de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia, in the Journal: (JOURNAL)

SUMMARY

Significant neuronal loss and microvacuolation were observed in the superior layers of frontal and temporal cortex, where some ballooned neurons were also observed (Fig 1c). The MAPT-G335S mutation was associated to neuronal tau pathology (tau positive neurons, NFT, neuropil threads) and glial tau pathology (coiled bodies, tau positive astrocytes), similarly to what the authors observed here . . .

 



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