HIGHLIGHTS
- who: Jakob M. Silberberg from the Institute Goethe University Oxford, Oxford, UK have published the research: Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors characterize the dynamics of ion coordination and translocation through the intersubunit tunnel by molecular dynamics (MD) simulations. The authors propose that the increase in ATPase activity observed for KdpFABF232AC is based on the acceleration of the rate-limiting_step in KdpFABC turnover, the E1-P/E2-P transition34, which is characterized by large rearrangements of the A domain12 . . .
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