Deciphering the active constituents of dabushen decoction of ameliorating osteoarthritis via ppar preservation by targeting dnmt1

HIGHLIGHTS

• who: PPARu03b3 and collaborators from the Dalian University, China have published the research work: Deciphering the active constituents of Dabushen decoction of ameliorating osteoarthritis via PPAR preservation by targeting DNMT1, in the Journal: (JOURNAL)
• what: The authors first established a rat model of OA to evaluate the efficacy of DD in the treatment of osteoarthritis. In this study, the binding free energies between the seven potential active constituents (isoliquiritigenin, emodin, taxifolin, catalpol, alisol A, zingerone, and schisandrin C) and DNMT1 complexes were calculated by the MM-GBSA method, and the results were showed that all . . .
  

   

  

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