Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region

HIGHLIGHTS

• who: Alexis Saintamand from the (UNIVERSITY) have published the paper: Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 17/02/2016
• what: The authors report that deconstructing the palindromic IgH 3'RR strongly affects its function even when enhancers are preserved. The authors report that the deconstruction of the IgH 3' palindrome widely affects SHM but only marginally affects CSR, showing that the unique architecture of the IgH locus 3' boundary crucially determines the full functional expression of the IgH . . .
  

   

  

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