HIGHLIGHTS
- What: The authors established melanoma metastasis models in mice to explore Dec`s functions and mechanisms in regulating MDSCs.
- Who: Posted Date November et al. from the Jiangsu Normal University have published the research work: Decitabine suppresses MDSC-induced immunosuppression through dual functional mechanism and inhibits melanoma metastasis, in the Journal: (JOURNAL)
- How: Dec inhibits melanoma metastasis and reduces MDSC populations in the lungs and bone marrow To evaluate Dec`s therapeutic efficacy against melanoma metastasis the authors developed a pulmonary metastatic melanoma mouse model and administered intraperitoneal injections of PBS or Dec . . .
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