Decoding molecular programs in melanoma brain metastases

HIGHLIGHTS

• who: Josefine Radke from the (UNIVERSITY) have published the research: Decoding molecular programs in melanoma brain metastases, in the Journal: (JOURNAL) of 16/02/2022
• what: The authors propose that the expression of Ecad and NGFR sub- classifies MBM and suggest that the Ecad-toNGFR phenotype switch is a rate-limiting process which potentially indicates drug-response and intracranial progression states in melanoma patients. Considering that the expression of NGFR in melanoma cells accompanies a network of associated genes such as mediators of a NCSC-phenotype34,92,93 - which was recently identified as a major . . .
  

   

  

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