HIGHLIGHTS
- who: Jonas Cerneckis from the DivisionDuarte, CA, USA The University have published the article: Decoding pseudouridine: an emerging target for therapeutic development, in the Journal: (JOURNAL)
- what: The authors focus only on studies that have demonstrated a translational defect in mutant DKC1-bearing cells although changes in rRNA Ψ levels have only been confirmed by Bellodi et_al .
- how: The authors identified small-molecule compounds that were potent inhibitors of PUS7 activity and suppressed GBM tumorigenesis suggesting that PUS7 inhibition could serve as a potential therapeutic approach to treat GBM. was attributed to the lack . . .
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