Decoding the anti-hypertensive mechanism of α-mangostin based on network pharmacology, molecular docking and experimental validation

HIGHLIGHTS

  • What: The authors aimed to decode the potential antihypertensive mechanisms α-MG through network pharmacology integrated with molecular docking and in_vivo experimental validation. This study showed that pathways in cancer, human cytomegalovirus infection, prostate cancer and chronic myeloid leukemia, and AGE-RAGE signaling pathway in diabetic complications might be involved in the effect of key therapeutic targets of α-MG.
  • Who: Qi-Qi Xue and collaborators from the Department of Cardiovascular Medicine, Shanghai Key Laboratory of University School of Medicine, Ruijin, nd Rd, Shanghai, China have published the paper: RESEARCH Open Access, in the Journal: (JOURNAL) of . . .

     

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