Deconvolution analysis identified altered hepatic cell landscape in primary sclerosing cholangitis and primary biliary cholangitis

HIGHLIGHTS

• What: Discussion: Although further studies are required to elucidate the roles of these hepatic cell phenotypes in cholestatic liver injury, the approach provides important implications that cell functions may differ depending on phenotypes, even in the same cell type during liver injury. This study aims to generate custom signature matrix files using liver scRNA-seq data and evaluate the effectiveness and reliability of CIBERSORTx with a custom signature matrix for hepatic cell phenotypes. To assess the accuracy of the cell composition estimated by CIBERSORTx, the authors compare it to established experimental data. In the current study, sc18sig . . .
  

   

  

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