Deconvolution of tumor composition using partially available dna methylation data

HIGHLIGHTS

  • who: Dingqin He from the College of Information University, Hucheng Ring Road, China have published the research: Deconvolution of tumor composition using partially available DNA methylation data, in the Journal: (JOURNAL)
  • what: Different from the available reference-based and reference-free methods, the proposed method PRMeth is based on partial reference information, which is more in line with real clinical practice.
  • how: The results showed that PRMeth outperformed the other five methods. The authors compared RPMM with six initialization approaches including five different clustering algorithms (i.e. canberra euclidean manhattan maximum and minkowski . . .

     

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