Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy

HIGHLIGHTS

• who: Marc Vervuurt from the We constructed two independent groups of sCAA patients for analysis (a discovery and a validation group), as well as separate groups of pre-symptomatic and symptomatic, CAA patients and respective age-matched controls (see Tables , and, )In the discovery cohort, we collected CSF samples of sCAA patients (n=27) and control subjects (n=40), all from the Radboud University Medical Center (Nijmegen, the Netherlands). sCAA patients were diagnosed using the modified Boston Criteria [5] and classified as probable (n=21) or possible CAA (n=2). Four patients who presented with both lobar . . .
  

   

  

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