HIGHLIGHTS
- who: Angela Castoldi from the SP, BrazilUniversity of have published the Article: Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88, in the Journal: (JOURNAL) of June/13,/2017
- what: The authors show that the whole-body MyD88 KO mice fed an HFD are heavier and more insulin resistant without increased systemic or AT inflammation. The authors show that Dectin-1 inhibition decreases the number of proinflammatory CD11c+ AT macrophages, which is consistent with Dectin-1dependent proinflammatory macrophage polarization in tumor and fungal infection models (Liu et_al, 2015; Loures et_al, 2014 . . .
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