Dedecreases in gap junction coupling recovers ca2+ and insulin secretion in neonatal diabetes mellitus, dependent on beta cell heterogeneity and noise

HIGHLIGHTS

• who: Aleena M. Notary and colleagues from the Department of Bioengineering, University of Colorado, Anschutz Medical campus, Aurora, Colorado have published the paper: DeDecreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise, in the Journal: (JOURNAL) of September/28,/2016
• what: The authors compared a computational model of islet electrical activity and insulin secretion against experimental measurements upon varied mutant KATP channel expression in the presence of different levels of gap junction coupling. The authors used experimental and computational methods to examine how . . .
  

   

  

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