HIGHLIGHTS
SUMMARY
Cuproptosis is regulated by protein lipoylation, and copper binds directly to the lipoylation constituents of the tricarboxylic_acid_cycle, which leads to the aggregation of lipoacylated proteins and the following loss of iron-sulfur cluster proteins, thus leading to proteotoxic stress and eventually cell death. The high-risk group patients had immunosuppressed, proliferatively active "cold" tumors, and the low-risk group patients had anti-tumor-active "hot" tumors. The authors predicted that patients in the low-risk group would show increased sensitivity to immunotherapy, whereas patients in the high-risk group would show more sensitivity to . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.