Deep proteome profiling of the hippocampus in the 5xfad mouse model reveals biological process alterations and a novel biomarker of alzheimer’s disease

HIGHLIGHTS

• who: Dong Kyu Kim from the XFAD mice (Tg [99] have published the article: Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimeru2019s disease, in the Journal: (JOURNAL)

SUMMARY

Accompanied by synaptic loss and neuroinflammation in the brain1. The hippocampus, which is essential for memory and cognitive function, is vulnerable to these pathological characteristics in AD patients2. The amyloid cascade hypothesis suggests that the production of amyloid beta (Aβ) is the initial amyloid-triggered reaction and that it initiates the subsequent . . .

 



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