Deep whole-genome resequencing sheds light on the distribution and effect of amphioxus snps

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SUMMARY

    Previous studies have revealed a contradictory phenomenon that extreme phenotypic similarity and highlevel genetic diversity co-exist in amphioxus populations. The authors resequenced 21 amphioxus (B. belcheri) genomes to over 100X depth using the Illumina HiSeq X Ten platform, selected the new haploid genome as the reference for joint SNP calling, and utilized AlphaFold2 to detect structural variant brought by SNPs. More than 11.5 million common SNPs were detected in the amphioxus population, which mainly affect genes enriched in ion transport, signal_transduction and cell adhesion, while protein structure analysis via AlphaFold2 revealed that . . .

     

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