HIGHLIGHTS
SUMMARY
Intracellular proteomic analysis shows increased monocyte numbers in hospitalized COVID-19 patients but impaired interferon-I response after stimulation. Given the challenges of comparing different patient severities in terms of time post-infection, the authors also examined whether time-post-symptom onset was associated with IFNα protein levels, but no significant associations were observed for each patient severity with the three separate assays (Fig S1d-f). Given the observed differences in IFNα2, but not all IFNα subtypes, at the plasma_protein level, the authors further explored potential differences in IFNα subtype expression using Nanostring . . .
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