Defective fatty acid oxidation in mice with muscle-specific acyl-coa synthetase 1 deficiency increases amino acid use and impairs muscle function

HIGHLIGHTS

• who: Liyang Zhao from the Animal studies Studies were performed with approval of and in accordance with the guidelines of the Institutional Animal Care and Use Committee at the University of North Carolina at Chapel HillMice were housed in a climate-controlled animal facility with ad libitum access to food (Prolab RMH , chow) and water. Littermate Acsl1flox/flox (63) mice served as controls. Acsl M⫺/⫺ mice were generated by crossing Acsl1flox/flox mice with mice expressing muscle-specific human skeletal actin promoter (Jackson Laboratory, catalog no., )-driven Cre recombinase (16). Mice were backcrossed six times onto the . . .
  

   

  

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