Deficits in mitochondrial tca cycle and oxphos precede rod photoreceptor degeneration during chronic hif activation

HIGHLIGHTS

• who: Vyara Todorova from the Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse, Schlieren, Switzerland have published the article: Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation, in the Journal: (JOURNAL) of 16/Dec/2005
• what: To identify mechanisms leading to the degeneration in this disease model, the authors focused on early alterations. Since anabolism is closely linked to energy metabolism, the authors focused on glycolysis and mitochondrial metabolism, including OXPHOS and the TCA cycle, to unravel the mechanistic basis of . . .
  

   

  

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