Defining clinical subtypes of adult asthma using electronic health records: analysis of a large uk primary care database with external validation

HIGHLIGHTS

SUMMARY

Subtypes of asthma have been defined, typically from clinical datasets on small, well-characterised subpopulations of asthma patients. The authors sought to define asthma subtypes from large longitudinal primary care electronic health records (EHRs) using cluster analysis. Asthma subtypes derived and validated in large independent EHR databases were primarily defined by level of ICS use, level of healthcare use, and presence of comorbidities. The recent review identified 63 studies that applied cluster analysis with the aim of defining asthma subtypes, and high­ lighted several practical and methodological limitations that were common across most of . . .

 



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