Delayed maturation of oligodendrocyte progenitors by microgravity: implications for multiple sclerosis and space flight

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SUMMARY

    The most recent culture system aims at instructing human induced pluripotent stem_cells (hiPS) to become mature, functional OLs. With the advent of human induced pluripotent stem_cells (hiPS) in 2006, for the first time, the possibility to make cells for transplantation where the donor would also be the recipient was a promise to all fields of regenerative medicine. Only a few aspects on the sensitivity of neural stem_cells to weightlessness (0 G) have been examined. In embryonic stem_cells (ESCs), microgravity reduces the differentiation and regenerative abilities, preserving them in a "stemness" state. To make OLPs . . .

     

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