HIGHLIGHTS
SUMMARY
Neuroimaging techniques, such as magnetic_resonance imaging (MRI), spectroscopy (MRS) and positron emission tomography (PET) are promising tools to achieve this goal by providing brain-specific information. The mechanisms and the causality relationship between peripheral metabolic alterations and dysfunction of the central mood regulation, and how this translates to in_vivo brain measurements, remain to be fully elucidated. In vivo 1H-magnetic_resonance spectroscopy (1H-MRS) Localized in_vivo 1H-magnetic_resonance spectroscopy (1H-MRS) was performed in the dorsal hippocampus (DH) and cingulate prefrontal cortex (PFC) of Crtc1-/- and WT mice. NAA concentration in DH was assumed to . . .
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