Deletion of gpatch2 does not alter tnf expression in mice

HIGHLIGHTS

• who: Destiny Dalseno from the (UNIVERSITY) have published the Article: Deletion of Gpatch2 does not alter Tnf expression in mice, in the Journal: (JOURNAL) of 14/03/2023
• what: The presence of two unique GPATCH2 targeting sgRNAs in the CRISPR screen was indicative of a true hit, which the authors aimed to confirm though ablation of Gpatch2 in a mouse model.

SUMMARY

Given the clear necessity of the TNF 3` UTR in maintaining appropriately low levels of TNF in_vivo, the authors sought to identify novel regulators of TNF mRNA that act . . .

 



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