Deletion of p1 arginine in a novel antithrombin variant (antithrombin london) abolishes inhibitory activity but enhances heparin affinity and is associated with early onset thrombosis*

HIGHLIGHTS

• who: Srikumar M. Raja from the (UNIVERSITY) have published the paper: Deletion of P1 Arginine in a Novel Antithrombin Variant (Antithrombin London) Abolishes Inhibitory Activity but Enhances Heparin Affinity and Is Associated with Early Onset Thrombosis*, in the Journal: (JOURNAL) of February/12,/2003

SUMMARY

The abnormal antithrombin was separated from the normal inhibitor by complexing the latter with thrombin followed by heparin-agarose affinity chromatography. Stopped-flow kinetic analysis showed that this was almost entirely due to a more favorable conformational activation of the variant than the normal inhibitor, as reflected by . . .

 



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