Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (−)-hosieine-a

HIGHLIGHTS

• who: ( )-hosieine-A and collaborators from the Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee , EHRadiation Lightsource, USA have published the article: Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (u2212)-hosieine-A, in the Journal: (JOURNAL)
• what: We sought to understand the chemical features and interactions that allow two alkaloid neurotoxins to influence nAChR ion_channels.
• how: A structure of a highly modified AcAChBP-(+)-anatoxin-a complex is present in the Protein Data Bank (PDB entry 4zjs Luo et_al 2009) but . . .
  

   

  

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