Delta opioid receptor agonists activate pi3k–mtorc1 signaling in parvalbumin-positive interneurons in mouse infralimbic prefrontal cortex to exert acute antidepressant-lie effects

HIGHLIGHTS

• What: The authors propose that selective DOP activation is a promising therapeutic strategy for the treatment of emotional disorders. The authors attempted to elucidate the cellular mechanisms underlying the antidepressant-like effects of DOP agonists. The authors aimed to determine whether mTOR signal_transduction is involved in the antidepressant-like effect, the specific brain region(s) in which the effect is exerted, the relationship between the effect and glutamatergic and/or GABAergic neuronal responses, and_(4) the cell-type specificity of DOP expression.
• Who: Toshinori Yoshioka from the Animals Male ICR mice, aged, weeks, were obtained . . .
  

   

  

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