Dendritic cell vaccination plus low-dose doxorubicin for the treatment of spontaneous canine hemangiosarcoma

HIGHLIGHTS

  • who: V. Konduri from the Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA have published the paper: Dendritic cell vaccination plus low-dose doxorubicin for the treatment of spontaneous canine hemangiosarcoma, in the Journal: (JOURNAL)
  • what: The authors report the analysis of a pilot phase I open-label trial of chemo-immunotherapy performed on consecutively presenting splenectomized canines with histologically verified HSA. This work has demonstrated that the loading of DC with antigenically similar (homologous) MHC class I and II antigens mediates a cellintrinsic upregulation of TH1 polarization. The aim of . . .

     

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