Depletion of plasma membrane⠍associated phosphoinositides mimics inhibition of trpm7 channels by cytosolic mg2+, spermine, and ph

HIGHLIGHTS

• who: Tetyana Zhelay from the (UNIVERSITY) have published the research work: Depletion of plasma membrane⠍associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg2+, spermine, and pH, in the Journal: (JOURNAL) of May/21,/2018
• what: This is in agreement with the experiments described in Fig 3, where PIP2 was depleted by VSP expression. This experiment demonstrated that channel sensitivity to Mg2⫹, polyamines, and protons strongly correlates with their sensitivity to PIP2 depletion, suggesting that they reflect the same process. The authors demonstrate that PIP2 depletion can mimic the inhibitory effects of internal Mg2 . . .
  

   

  

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