HIGHLIGHTS
- who: Tom Van Dooren and collaborators from the (UNIVERSITY) have published the research work: Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease, in the Journal: (JOURNAL) of 27/08/2014
SUMMARY
Intraneuronal Signaling and Endocytosis Are Dysregulated in AD Leading to Increased A?o Formation and TAU-Phosphorylation, which in Turn Further Derange Signalling 2.1. Risk factor Possible mechanism(s)* A? homeostasis Cellular signaling Genetic APP PS1 PS2 BACE ApoE4 SORLA EPHA1 MS4A6A/MS4A4A CD2AP APP processing Change in A?40/A?42 ratio APP processing APP processing . . .
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