HIGHLIGHTS
- who: Christian J. G. Tessier from the (UNIVERSITY) have published the paper: Derepression may masquerade as activation in ligand-gated ion channels, in the Journal: (JOURNAL) of 26/08/2022
- what: Taking advantage of a reconstructed ancestral muscle-type u03b2-subunit that forms spontaneously activating homopentamers, here the authors show that incorporation of human muscle-type u03b1-subunits appears to repress spontaneous activity, and furthermore that the presence of agonist relieves this apparent u03b1-subunit-dependent repression. This analysis showed an apparent correlation between the amplitude and duration of bursts, with lower amplitude bursts being . . .
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