Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the heparg cell line

HIGHLIGHTS

SUMMARY

In recent years, numerous applications of metabolomics to chemical safety assessment have been proposed (e_g, mode-of-action (MoA) discovery as well as chemical grouping and readacross), although regulatory acceptance of metabolomics studies has yet to be achieved (van Ravenzwaay et_al 2012, 2016; Van den Eede et_al 2015; Cuykx et_al 2018; Dubuis et_al 2018; Ramirez et_al 2018; Zampieri et_al 2018). Calculating POD values from in_vitro experiments is an attractive option to increase throughput of toxicological experiments at lower cost, and without the need for vertebrate testing. This approach additionally requires extrapolation of in_vitro concentrations . . .

 



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