HIGHLIGHTS
- who: Biao Ruan from the (UNIVERSITY) have published the article: Design and characterization of a protein fold switching network, in the Journal: (JOURNAL) of 14/07/2022
- what: The authors determine that both GA and GB can switch into a third fold (u03b1/u03b2-plait) and show that these three folds and four functions (HSA-binding, IgG-binding, protease inhibition, and RNA-binding) can be connected in a network that avoids unfolded and functionless states. The authors describe how these nodes were engineered, determine key structures using NMR spectroscopy, and analyze stability and binding function . . .
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