Design and immunological evaluation of two-component protein nanoparticle vaccines for east coast fever

HIGHLIGHTS

  • who: Anna Lacasta and collaborators from the University of Copenhagen, Denmark have published the paper: Design and immunological evaluation of two-component protein nanoparticle vaccines for East Coast fever, in the Journal: (JOURNAL)
  • what: In this experiment, the sporozoite challenge was calculated to be ~LD70. The study provides new information on the immunogenicity of the I32-28 scaffold. In the present study, each of the three computationally designed nanoparticles the authors directly compared displayed 60 copies of p67C, so the difference in their immunological performance must be attributed to other factors.
  • how: The . . .

     

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