HIGHLIGHTS
SUMMARY
The synthesis of biologically significant compounds is based mainly on the ability to introduce an appropriate group of atoms into a target molecule. In literature, there areare many examples of various properties and biological activiactivities of phosphonic acid derivatives containing a hydroxyl group and/or Inthe the literature, there many examples of various properties and biological ties of phosphonic acid derivatives containing a hydroxyl group and/or fluorine fluorine in α position to aderivatives phosphonate group. The most mostreliable reliable approaches widely the synthesis of both fluorineand non-fluorinated phosphonate derivatives are the Pudovik reaction . . .
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