HIGHLIGHTS
- who: Dahae Hailey Bae from the Center for Biologics Craniofacial Research, NIH, Bethesda, MD, USA have published the paper: Design and Testing of Vector-Producing HEK293T Cells Bearing a Genomic Deletion of the SV40 T Antigen Coding Region, in the Journal: (JOURNAL) of 18/09/2020
- what: The authors deleted the SV40 T antigen-encoding_sequences in HEK293T_cells using a CRISPR-Cas9 approach and determined the impact on lentiviral_vector and AAV vector titers. The work has revealed that the removal of the T antigen-encoding_sequence only marginally reduced lentiviral titers, supporting the notion that additional cellular . . .
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